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Published on: March 1, 2022
Normal bone turnover in transient hyperphosphatasemia
Stepan Kutilek1, Barbora Cervickova, Pavla Bebova
1University of Pardubice, Pardubice Hospital and Faculty of Health Studies, Pediatrics, Pardubice, Czech Republic. stepan.kutilek@nemocnice-pardubice.cz
Summary
Transient hyperphosphatasemia of infancy and early childhood (THI) is a benign condition with temporary high alkaline phosphatase (ALP). This study shows normal bone turnover in THI, suggesting no need for further investigation.
Area of Science:
- Pediatrics
- Biochemistry
- Endocrinology
Background:
- Transient hyperphosphatasemia of infancy and early childhood (THI) presents as a temporary, isolated elevation of serum alkaline phosphatase (ALP) in young children.
- While THI is considered benign, the elevated ALP levels can cause concern, particularly in seriously ill children.
- Previous hypotheses suggested THI might be linked to increased bone turnover.
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