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Prevalence of influenza virus among the paediatric population in Mumbai during 2007-2009

S Roy1, D Patil, R Dahake

  • 1Department of Virology, Haffkine Institute, Mumbai 400 012, India.

Indian Journal of Medical Microbiology
|June 6, 2012
PubMed

Insights

Influenza A and B viruses are prevalent in Mumbai children with acute respiratory infections. Molecular methods detected 11% positivity, highlighting the need for surveillance in pandemic preparedness.

Area of Science:

  • Virology
  • Public Health
  • Epidemiology

Background:

  • Influenza significantly impacts global public health, affecting 15-20% of the population annually.
  • Limited data exists on influenza virus activity specifically within Mumbai.

Purpose of the Study:

  • To determine the prevalence of influenza viruses in children experiencing acute respiratory infections in Mumbai.
  • To utilize molecular methods for accurate influenza detection.

Main Methods:

  • Collected 100 respiratory samples (nasal and throat swabs) from pediatric patients in Mumbai between July 2007 and July 2009.
  • Employed real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) to detect influenza A (H1, H3) and influenza B.
  • Followed World Health Organization (WHO) guidelines for sample collection and processing.

Main Results:

  • 11% (11 out of 100) of samples tested positive for influenza virus.
  • Influenza A subtypes detected included H1 (1%) and H3 (5%).
  • Influenza B virus was found in 5% of the samples.

Conclusions:

  • Both influenza A and B viruses circulated in Mumbai during the study period.
  • Surveillance data is crucial for early detection of antigenic variants.
  • Findings support global influenza vaccine development and pandemic preparedness efforts.
Abstract

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