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Cognitive functioning in prodromal psychosis: a meta-analysis.

Paolo Fusar-Poli¹, Giacomo Deste, Renata Smieskova

¹Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, England, UK. p.fusar@libero.it

Archives of General Psychiatry

|June 6, 2012

Summary

This summary is machine-generated.

Individuals at clinical high risk (HR) for psychosis show widespread cognitive deficits, including in memory and verbal fluency. These impairments worsen with the transition to psychosis, highlighting their role as vulnerability markers.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

A significant number of individuals at clinical high risk (HR) for psychosis transition to a psychotic disorder.
Cognitive deficits may precede psychosis onset and indicate vulnerability.

Purpose of the Study:

To quantitatively synthesize findings on cognitive functioning in individuals at HR for psychosis.
To identify cognitive markers associated with psychosis risk and transition.

Main Methods:

Systematic literature search of electronic databases up to January 2011.
Inclusion of 19 studies with 1188 HR subjects and 1029 controls.
Extraction of neurocognitive, social cognition, and demographic/clinical variables.

Main Results:

HR subjects demonstrated significant impairments in general intelligence, executive function, memory, verbal fluency, attention, working memory, and social cognition compared to controls.
Processing speed was also affected, though not significantly.
Worsened verbal fluency and memory deficits were linked to later transition to psychosis.

Conclusions:

The high-risk state for psychosis is characterized by broad neurocognitive and social cognition impairments.
Deficits in verbal fluency and memory are particularly associated with the transition to psychosis.