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Related Experiment Video

Updated: May 21, 2026

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
04:09

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors

Published on: February 13, 2026

Endoscopic submucosal dissection--current success and future directions.

Hironori Yamamoto1

  • 1Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. ireef@jichi.ac.jp

Nature Reviews. Gastroenterology & Hepatology
|June 6, 2012
PubMed
Summary
This summary is machine-generated.

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Endoscopic submucosal dissection (ESD) offers complete resection for early gastrointestinal tumors. This advanced technique shows low recurrence rates and holds potential for worldwide adoption in treating these neoplasms.

Area of Science:

  • Gastroenterology
  • Endoscopic Surgery
  • Oncology

Background:

  • Endoscopic submucosal dissection (ESD) was developed in Japan over a decade ago.
  • ESD allows for complete, en bloc resection of superficial gastrointestinal neoplasms.
  • Technological advancements have improved ESD's efficacy despite its technical challenges.

Purpose of the Study:

  • To review the efficacy and outcomes of endoscopic submucosal dissection (ESD) for gastrointestinal neoplasms.
  • To highlight the benefits of en bloc resection for accurate histopathologic assessment.
  • To discuss the current status and future potential of ESD in Western countries.

Main Methods:

  • Review of existing literature on endoscopic submucosal dissection (ESD) outcomes.
  • Analysis of therapeutic results and recurrence rates reported globally.

Related Experiment Videos

Last Updated: May 21, 2026

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
04:09

The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors

Published on: February 13, 2026

  • Discussion of technological advancements and future applications of ESD.

    • Main Results:

    • ESD enables complete resection of gastrointestinal neoplasms, regardless of size or location.
    • En bloc resection facilitates accurate histopathologic examination, crucial for metastasis risk assessment.
    • Low tumor recurrence rates are reported following ESD, particularly in Asian countries.
    • Promising results are emerging from European countries, despite initial skepticism.

    Conclusions:

    • ESD is a highly effective treatment for early gastrointestinal neoplasms, achieving curative outcomes.
    • The technique's success relies on en bloc resection and precise histopathology.
    • Continued technological development, including endoscopic robotics, may establish ESD as a global standard for early gastrointestinal neoplasm treatment.