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Updated: Aug 2, 2026
Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
c-erbB-2 oncogene expression in ovarian cancer
J S Haldane1, V Hird, C M Hughes
1Department of Histopathology, Hammersmith Hospital, London, U.K.
This study investigated c-erbB-2 expression in ovarian cancer, finding no adverse prognostic effect. Results suggest c-erbB-2 staining patterns do not worsen outcomes for these patients.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- The c-erbB-2 oncoprotein is implicated in various cancers.
- Its role in ovarian cancer prognosis requires further elucidation.
Purpose of the Study:
- To evaluate the prognostic significance of c-erbB-2 expression in common epithelial ovarian malignancies.
Main Methods:
- Immunohistochemical staining for c-erbB-2 was performed on 104 ovarian tumor samples.
- Analysis included cytoplasmic and membrane staining patterns.
- Multivariate Cox regression assessed relative risks with known prognostic factors.
Main Results:
- Cytoplasmic staining for c-erbB-2 was observed in 22.1% of cases.
- Combined membrane and cytoplasmic staining occurred in 8.7% of cases.
- Multivariate analysis indicated no adverse prognostic effect for cytoplasmic staining alone (RR 1.456, P>0.1) and a potentially favorable effect for combined staining (RR 0.316, P<0.005).
Conclusions:
- The findings do not support an adverse prognostic role for c-erbB-2 in this cohort of ovarian cancer patients.
- Specific c-erbB-2 staining patterns may not be indicative of poorer outcomes.
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