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Published on: November 30, 2022
One-pot synthesis of β-acetamido ketones using boric acid at room temperature
Zahed Karimi-Jaberi1, Korosh Mohammadi
1Department of Chemistry, Firoozabad Branch, Islamic Azad University, P.O. Box 74715-117, Fars, Firoozabad, Iran. zahed.karimi@yahoo.com
Abstract:
β-acetamido ketones were synthesized in excellent yields through one-pot condensation reaction of aldehydes, acetophenones, acetyl chloride, and acetonitrile in the presence of boric acid as a solid heterogeneous catalyst at room temperature. It is the first successful report of boric acid that has been used as solid acid catalyst for the preparation of β-acetamido ketones. The remarkable advantages offered by this method are green catalyst, mild reaction conditions, simple procedure, short reaction times, and good-to-excellent yields of products.
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