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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Prevalence of methicillin-resistant Staphylococcus aureus and its antibiotic susceptibility pattern in a tertiary

Shreekant Tiwari1, Manisa Sahu, Bibhudutta Rautaraya

  • 1Department of Microbiology, Hi-Tech Medical College Bhubaneswar 751025.

Journal of the Indian Medical Association
|June 7, 2012
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) is a growing concern. This study screened clinical samples, finding MRSA in 55.8% of strains, with high sensitivity to vancomycin and linezolid.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) emerged in the 1960s as a significant nosocomial pathogen.
  • MRSA causes increased mortality, morbidity, and healthcare costs, with early reports from Malaysia in 1972.
  • The study addresses the need to screen clinical samples for MRSA and assess its antibiotic susceptibility.

Purpose of the Study:

  • To screen clinical samples for the presence of Methicillin-resistant Staphylococcus aureus (MRSA).
  • To determine the antibiotic susceptibility patterns of isolated MRSA strains.
  • To identify effective anti-MRSA agents and promote rational antibiotic use.

Main Methods:

  • Isolation and identification of Staphylococcus aureus strains from various clinical samples over a one-year period (May 2008-May 2009).
  • Screening of isolated strains for Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA).
  • Antibiotic susceptibility testing was performed on MRSA isolates.

Main Results:

  • Out of 204 Staphylococcus aureus strains, 114 (55.8%) were identified as MRSA.
  • MRSA was most frequently isolated from pus (45%), urine (20.5%), catheter tips (80%), blood (66.7%), and pus (58.7%).
  • MRSA strains demonstrated 100% sensitivity to vancomycin and linezolid, and 92.9% sensitivity to teicoplanin.

Conclusions:

  • Vancomycin and linezolid are highly effective against the studied MRSA strains.
  • Antibiotics other than vancomycin can be considered for MRSA treatment, pending sensitivity testing.
  • Avoiding irrational and indiscriminate antibiotic use is crucial in managing MRSA infections.

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