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Updated: May 21, 2026

Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

[Histamine intolerance and pseudoallergy--do they exist?].

Matti Hannuksela, Tari Haahtela

Duodecim; Laaketieteellinen Aikakauskirja

|June 7, 2012

Summary

This summary is machine-generated.

Histamine intolerance (HIT) is a debated condition where the body reacts to food histamine. Diagnosis relies on symptoms, as objective tests are lacking, and the terms are not recommended.

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Published on: September 16, 2011

Area of Science:

Food science
Clinical immunology
Gastroenterology

Context:

Histamine intolerance (HIT) is a condition characterized by adverse reactions to histamine found in food.
Symptoms often include headaches, urticaria, and abdominal discomfort.
Certain foods like fruits, nuts, spices, and additives are suspected triggers, termed pseudoallergens.

Purpose:

To review the current understanding and diagnostic challenges of histamine intolerance.
To evaluate the scientific basis for the terms 'histamine intolerance' and 'pseudoallergens'.

Summary:

HIT is a syndrome where individuals react to histamine from food, presenting with symptoms like headache and urticaria.
Diagnosis is currently based on subjective symptom reporting due to a lack of objective diagnostic methods.
The scientific literature suggests a need for better clinical studies to clarify the phenomenon.

Impact:

The current lack of objective evidence makes the diagnosis of HIT difficult.
The terms 'histamine intolerance' and 'pseudoallergens' are considered unclear and their use is not recommended in scientific literature.
Further research is required to establish clear diagnostic criteria and understand the underlying mechanisms.