Related Experiment Video

Updated: May 21, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

The role of periostin in eosinophilic otitis media

Hisanori Nishizawa1, Atsushi Matsubara, Takashi Nakagawa

  • 1Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Japan.

Acta Oto-Laryngologica
|June 7, 2012
PubMed
Abstract

Insights

Periostin is present in the middle ear of patients with eosinophilic otitis media (EOM) and in a new EOM animal model. This suggests periostin is key in developing middle ear fibrosis in EOM.

Area of Science:

  • Otolaryngology
  • Immunology
  • Pathology

Background:

  • Eosinophilic otitis media (EOM) is a chronic inflammatory condition of the middle ear.
  • The role of specific proteins in EOM pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the presence and role of periostin in the middle ear of EOM patients.
  • To examine periostin expression in a newly developed animal model of EOM.

Main Methods:

  • Histological and immunohistochemical analyses were performed on middle ear specimens from EOM patients.
  • An EOM animal model was created using ovalbumin sensitization.
  • Periostin localization was assessed in both human samples and the animal model.

Main Results:

  • Periostin-positive immunostaining was detected in the middle ear sections of EOM patients.
  • The EOM animal model exhibited eosinophil infiltration and thickened mucosa.
  • Periostin was found in the extracellular matrix of the middle ear mucosa in the animal model.

Conclusions:

  • Periostin is present in the middle ear tissues affected by EOM.
  • The findings indicate periostin's significant involvement in subepithelial fibrosis within the middle ear during EOM.
  • Periostin may be a potential therapeutic target for managing EOM-related fibrosis.

More Related Videos

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Related Concept Videos

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...