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Updated: May 21, 2026

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells
M Nagaraju1, E Gnana Deepthi, C Ashwini
1Organic Chemistry Division-II, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
Bioorganic & Medicinal Chemistry Letters
|June 7, 2012
Abstract:
A new class of hybrid chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.
