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Updated: May 21, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Stereoprogrammed direct synthesis of calixarene-based [3]rotaxanes
Carmen Talotta1, Carmine Gaeta, Placido Neri
1Dipartimento di Chimica e Biologia and NANO_MATES Research Center, Università di Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy.
Abstract:
Directional calixarene wheels were threaded along a bis(benzylalkylammonium) axle in a stereoprogrammed way to obtain the first examples of calixarene-based [3]rotaxanes. The base/acid treatment demonstrated that these systems act as nanosized molecular shuttles. An unprecedented switching between the tail-to-tail and head-to-head relative orientation of the calix-wheels was observed.
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