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Updated: May 21, 2026
10:04
Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
The complexity of HIV vasculopathy
Alan Stanley1, Sally Candy, Candyce Levin
1Department of Medicine, University of Cape Town. alan.stanley@uct.ac.za
Summary
This case study highlights diagnosing stroke in human immunodeficiency virus (HIV) patients. We recommend testing for varicella zoster virus (VZV) and treating with acyclovir if suspected, alongside HIV management.
Area of Science:
- Neurology
- Infectious Diseases
- Vascular Medicine
Background:
- Stroke is a serious complication in individuals with human immunodeficiency virus (HIV).
- Aneurysmal vasculopathy presents diagnostic challenges in HIV-infected individuals.
- Identifying the specific etiology of vasculopathy is crucial for effective treatment.
Observation:
- A case of stroke linked to HIV infection and aneurysmal vasculopathy is presented.
- Diagnostic difficulties in determining the cause of vasculopathy were encountered.
- Varicella zoster virus (VZV) replication in cerebrospinal fluid (CSF) was investigated.
Findings:
- Polymerase chain reaction (PCR) testing of CSF for VZV is recommended.
- Intravenous acyclovir treatment is suggested for suspected VZV reactivation.
- Antiretroviral therapy for HIV control and antiplatelet agents are essential components of management.
Implications:
- Early detection and treatment of VZV are critical, even with negative CSF PCR results after 2 weeks.
- This approach aids in managing stroke in HIV patients with unclear vasculopathy etiology.
- Further research into VZV's role in HIV-associated vasculopathy is warranted.
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