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Related Concept Videos

Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: May 21, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Structural substrates for resting network disruption in temporal lobe epilepsy.

Natalie L Voets1, Christian F Beckmann, David M Cole

  • 1Neuroimaging of Epilepsy Laboratory, Department of Neurology and McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4 Canada.

Brain : a Journal of Neurology
|June 7, 2012
PubMed
Summary
This summary is machine-generated.

Resting-state functional connectivity is altered in temporal lobe epilepsy, with reduced network integration linked to grey matter density and white matter coherence. This impacts brain networks crucial for function.

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Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Systems Neuroscience

Background:

  • Resting-state functional magnetic resonance imaging (fMRI) assesses brain network organization.
  • Previous studies in temporal lobe epilepsy (TLE) used limited region-of-interest approaches.
  • A comprehensive, whole-brain analysis of functional connectivity in TLE is needed.

Purpose of the Study:

  • To quantify whole-brain functional connectivity in resting-state networks in TLE.
  • To investigate the relationship between functional connectivity and structural pathology (grey matter density and white matter coherence).

Main Methods:

  • Acquired resting-state fMRI, diffusion tensor imaging (DTI), and anatomical MRI data from 35 TLE patients and 20 controls.
  • Utilized independent component analysis (ICA) for objective, whole-brain functional connectivity quantification.
  • Performed group comparisons and assessed associations with grey matter density and fractional anisotropy (FA).

Main Results:

  • Patients with TLE exhibited altered functional connectivity, notably reduced connectivity involving the hippocampus, temporal, and precentral cortices.
  • Reduced hippocampal network integration correlated with grey matter density.
  • Functional connectivity in other regions showed atypical associations with white matter coherence (FA).

Conclusions:

  • Cortical atrophy and white matter microstructural damage significantly impact resting-state functional connectivity in TLE.
  • Multimodal imaging reveals distributed network alterations in TLE beyond localized structural damage.
  • Findings highlight the importance of considering large-scale network disruptions in TLE.