Escherichia coli: great diversity around a common core
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Updated: May 21, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
Danilo G Moriel1, Roberto Rosini, Kate L Seib
1Novartis Vaccines and Diagnostics, Sienna, Italy.
Unlabelled:
Escherichia coli outbreak in Germany, which resulted in more than 4,000 cases, including 908 cases of hemolytic-uremic syndrome (HUS) and at least 50 deaths, highlighted the genome plasticity of E. coli and the potential for new virulent strains to emerge. The analysis of 170 E. coli genome sequences for the presence of nine previously identified protective extraintestinal pathogenic E. coli antigens suggested the feasibility of a combination vaccine as a universal intervention against all pathogenic E. coli strains.
Importance:
This article reports on the feasibility of a combination vaccine as a universal intervention against all pathogenic Escherichia coli strains.
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