Related Experiment Video
Updated: May 21, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
Published on: October 20, 2014
The Prdm family: expanding roles in stem cells and development
Tobias Hohenauer1, Adrian W Moore
1Disease Mechanism Research Core, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.
Abstract:
Members of the Prdm family are characterized by an N-terminal PR domain that is related to the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific DNA binding and protein-protein interactions. Prdm factors either act as direct histone methyltransferases or recruit a suite of histone-modifying enzymes to target promoters. In this way, they function in many developmental contexts to drive and maintain cell state transitions and to modify the activity of developmental signalling pathways. Here, we provide an overview of the structure and function of Prdm family members and discuss the roles played by these proteins in stem cells and throughout development.
More Related Videos
Related Concept Videos
Lineage Commitment
Maintenance of the ES Cell State
Multipotency of Hematopoietic Stem Cells
Stem Cell Culture
Regulation of Hematopoietic Stem Cells
Source And Potency Of Stem Cells

