Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Reactions

Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retraction Note: Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways.

Scientific reports·2026

Same author

Association between community medicine rotation duration and general medicine in-training examination scores among second-year resident physicians in Japan: a nationwide cross-sectional study.

BMC medical education·2026

Same author

Lessons in clinical reasoning: a case of a boy who continued crying after falling.

Diagnosis (Berlin, Germany)·2026

Same author

Nationwide survey of formal mentorship characteristics and perceptions among resident physicians in Japan.

BMC medical education·2026

Same author

Agreement Between Reasoning-Oriented Generative AI Models and Clinical Educators in Evaluating Japanese Objective Structured Clinical Examination Transcripts: Preliminary Comparative Study.

JMIR formative research·2026

Same author

Associations of marital status with well-being and career intentions among medical residents: a national survey in Japan.

Academic medicine : journal of the Association of American Medical Colleges·2026

Search research articles

Related Experiment Video

Updated: May 21, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Exercise-induced anaphylaxis.

Taro Shimizu¹, Yasuharu Tokuda

¹Emory University, Atlanta, Georgia, USA. shimizutaro7@gmail.com

BMJ Case Reports

|June 7, 2012

Summary

This summary is machine-generated.

Vigorous exercise can trigger exercise-induced anaphylaxis, a serious allergic reaction causing collapse. Early recognition and management, alongside preventative strategies, are crucial for patient safety.

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Related Experiment Videos

Last Updated: May 21, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

Allergy and Immunology
Sports Medicine
Emergency Medicine

Background:

Exercise-induced anaphylaxis is a rare but potentially life-threatening condition.
It is characterized by allergic symptoms occurring during or after physical exertion.
Diagnosis relies heavily on patient history and exclusion of other causes.

Observation:

A 23-year-old male experienced acute flushing, pruritus, warmth, and collapse post-vigorous exercise.
Symptoms resolved after rest and intravenous saline infusion.
A similar episode occurred 5 years prior during exercise, with no identifiable co-triggers.

Findings:

The patient's presentation was consistent with exercise-induced anaphylaxis.
The condition was not associated with any specific co-factors or triggers.
The patient recovered fully without complications after medical guidance.

Implications:

Highlights the importance of considering exercise-induced anaphylaxis in athletes presenting with collapse post-exercise.
Emphasizes the need for patient education on trigger avoidance and emergency preparedness.
Underscores the role of prompt medical intervention in managing acute episodes.