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Updated: May 21, 2026
12:22
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Shingles with secondary asymptomatic CNS involvement!
Syed Viqar Ahmed1, Hazim Hamada, Chaminda Jayawarna
1Acute Medicine Unit, Stepping Hill Hospital, Stockport, UK. syedviqarahmed@hotmail.com
BMJ Case Reports
|June 7, 2012
Summary
Varicella zoster virus (VZV) reactivation caused a rare T3 dermatome herpes zoster infection in a young woman. Prompt diagnosis and treatment with intravenous acyclovir led to a full recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Herpes zoster, caused by varicella zoster virus (VZV) reactivation, is uncommon in young, immunocompetent individuals.
- Early symptoms can include dermatomal pain, headache, and vomiting, mimicking other neurological conditions.
Observation:
- A 32-year-old woman presented with interscapular pain, headache, and vomiting.
- Examination revealed herpes zoster affecting the T3 dermatome without neurological deficits or meningeal signs.
Findings:
- Cerebrospinal fluid analysis showed elevated protein, lymphocytic pleocytosis, and positive VZV PCR.
- HIV serology was negative, ruling out an underlying immunodeficiency state.
Implications:
- This case highlights the importance of considering VZV reactivation in young adults presenting with atypical neurological symptoms.
- Early diagnosis and aggressive antiviral therapy are crucial for favorable outcomes in VZV neurological complications.
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