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Liposomal amphotericin B treatment in a 9-month-old liver recipient

J Tollemar1, F Duraj, B G Ericzon

  • 1Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.

Mycoses
|May 1, 1990
PubMed

Insights

A 9-month-old infant received liposomal amphotericin B for candidemia following a liver transplant for Pompe disease. This marks the youngest documented use of this antifungal medication.

Area of Science:

  • Pediatric Hepatology
  • Transplant Medicine
  • Mycology

Background:

  • Liver transplantation is a critical treatment for inherited metabolic disorders like Pompe disease.
  • Candidemia is a serious fungal infection that can complicate post-transplant recovery.
  • Liposomal amphotericin B is a potent antifungal agent used for invasive fungal infections.

Observation:

  • A 9-month-old male infant underwent liver transplantation for Pompe disease.
  • The patient developed a suspected bloodstream fungal infection (candidemia).

Findings:

  • Treatment was initiated with liposomal amphotericin B (AmBisome).
  • This represents the youngest reported patient to receive this specific antifungal therapy.

Implications:

  • The use of liposomal amphotericin B in such a young pediatric transplant recipient expands its known safety and efficacy profile.
  • Early and effective antifungal treatment is crucial for improving outcomes in pediatric liver transplant patients with invasive fungal infections.
  • Further research may explore the optimal dosing and duration of liposomal amphotericin B in neonates and infants post-transplantation.

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