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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Cross-reactivity

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Related Experiment Video

Updated: May 21, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

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Published on: May 31, 2021

Food allergy.

Youngshin Han1, Jihyun Kim, Kangmo Ahn

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean Journal of Pediatrics
|June 7, 2012
PubMed
Summary
This summary is machine-generated.

Food allergy affects 5% of Korean children, involving immune responses to food proteins. Management includes avoidance, prompt treatment, and nutritional support for this significant public health issue.

Keywords:
AllergensCross reactionsDisease managementFood allergy

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Area of Science:

  • Immunology
  • Public Health
  • Nutrition

Background:

  • Food allergy is a significant public health concern, impacting 5% of infants and children in Korea.
  • It is characterized by immune responses to food proteins and is linked to atopic dermatitis and anaphylaxis.
  • Food allergen sensitization can occur via the gastrointestinal tract or through cross-reactivity with inhalant allergens.

Purpose of the Study:

  • To define food allergy and examine its prevalence.
  • To explore the characteristics of food allergens.
  • To review current management strategies for food allergies.

Main Methods:

  • This review synthesizes existing literature on food allergy.
  • It examines epidemiological data on prevalence.
  • It analyzes the structural and immunological characteristics of food allergens.

Main Results:

  • Food allergy affects a notable percentage of the pediatric population.
  • Two classes of food allergy sensitization are identified: gastrointestinal and cross-reactive.
  • Food allergenicity is influenced by structural factors and food processing.

Conclusions:

  • Effective food allergy management relies on dietary avoidance, timely treatment of reactions, and nutritional support.
  • Understanding allergen characteristics is crucial for developing better diagnostic and therapeutic approaches.
  • Continued research is needed to address this growing public health challenge.