Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific differences in clinical characteristics and organ damage in Hypertensive Urgencies.

Internal and emergency medicine·2026
Same author

Psychological Burden in Uncontrolled Hypertension: Findings from the ERIDANO Multicenter Study.

Journal of clinical medicine·2026
Same author

Substrate Stiffness Modulates Cell-Network Topology in Human-Derived Neurons.

ACS omega·2026
Same author

Redefining Vascular Monitoring: A Wearable with Force Sensor Resistors for Real-Time Pulse Wave Velocity Assessment.

IEEE transactions on bio-medical engineering·2026
Same author

Heart failure associated with renal artery stenosis and Pickering syndrome: the critical role of endovascular revascularization: a case series and meta-analysis.

Clinical hypertension·2026
Same author

"Short-term prognosis of hypertensive emergencies and urgencies: second preliminary report of the ongoing Italian multicenter ERIDANO study".

Hypertension research : official journal of the Japanese Society of Hypertension·2026

Related Experiment Video

Updated: May 21, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Left heart morphology and function in primary aldosteronism.

Alberto Milan1, Corrado Magnino, Ambra Fabbri

  • 1Department of Medicine and Experimental Oncology, Division of Internal Medicine, Hypertension Unit, University of Turin, Turin, Italy.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|June 8, 2012
PubMed
Summary
This summary is machine-generated.

Primary aldosteronism, a common cause of secondary hypertension, leads to more cardiovascular events than essential hypertension. This review details left heart changes in primary aldosteronism.

Related Experiment Videos

Last Updated: May 21, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Area of Science:

  • Cardiology
  • Endocrinology
  • Hypertension Research

Background:

  • Primary aldosteronism is the most common cause of secondary hypertension, affecting up to 11% of patients.
  • Patients with primary aldosteronism exhibit increased cardiovascular and cerebrovascular event rates compared to essential hypertension patients, even with similar blood pressure.
  • Cardiac organ damage differences between primary aldosteronism and essential hypertension have been investigated through echocardiography.

Purpose of the Study:

  • To summarize current knowledge on structural and functional alterations of the human left heart in primary aldosteronism.
  • To provide insights into the mechanisms underlying increased cardiovascular risk in primary aldosteronism.

Main Methods:

  • Literature review of studies investigating cardiac organ damage in primary aldosteronism.
  • Analysis of echocardiographic data comparing left heart alterations in primary aldosteronism versus essential hypertension.

Main Results:

  • Primary aldosteronism is associated with distinct structural and functional left heart changes compared to essential hypertension.
  • These changes may contribute to the higher prevalence of cardiovascular events observed in primary aldosteronism.

Conclusions:

  • Understanding left heart alterations in primary aldosteronism is crucial for risk stratification and management.
  • Further research is needed to elucidate the precise mechanisms and guide targeted therapies.