Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibiotic resistance of urinary pathogens after kidney transplantation: a 10-year single-center survey in Germany.

Infection·2025
Same author

Penetration of MeV electrons into the mesosphere accompanying pulsating aurorae.

Scientific reports·2021
Same author

[Kidney function in contrast media-enhanced imaging].

Der Radiologe·2019
Same author

Autophagy activation in circulating proangiogenic cells aggravates AKI in type I diabetes mellitus.

American journal of physiology. Renal physiology·2018
Same author

[Epidemiological analysis of malaria prevalence in Jiangsu Province in 2015].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2018
Same author

[Diagnostic knowledge and skills of parasitic diseases based on competition of professional personnel in Jiangsu Province, China].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2018

Related Experiment Video

Updated: May 21, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Peripherally circulating CD4⁺ FOXP3⁺ CXCR3⁺ T regulatory cells correlate with renal allograft function.

A Hoerning1, S Köhler, C Jun

  • 1Department of Pediatrics II, Pediatric Nephrology, Gastroenterology, Endocrinology and Transplant Medicine, Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.

Scandinavian Journal of Immunology
|June 8, 2012
PubMed
Summary

T regulatory cell (Treg) trafficking receptors CXCR3 and CCR5 are linked to kidney transplant success. Tacrolimus-based immunosuppression, unlike cyclosporine A, supports Treg homing receptor expression, improving allograft function.

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Related Experiment Videos

Last Updated: May 21, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Area of Science:

  • Immunology
  • Transplantation Science
  • Cellular Biology

Background:

  • Peripheral immunoregulation relies on T regulatory cell (Treg) trafficking to allografts.
  • The role of Treg trafficking receptors in human solid organ transplantation remains unclear.

Purpose of the Study:

  • To analyze chemokine receptor expression (CXCR3, CCR5) on Tregs in renal transplant recipients.
  • To correlate Treg receptor expression with allograft function and immunosuppressive drug effects.

Main Methods:

  • Flow cytometry analysis of peripheral blood mononuclear cells from 54 renal transplant recipients.
  • Correlation analysis of chemokine receptor expression (CXCR3, CCR5) on CD4+ FOXP3+ Tregs with estimated glomerular filtration rate (eGFR).

Main Results:

  • CXCR3 and CCR5 expression on Tregs correlated positively with renal allograft function (eGFR) in patients on tacrolimus.
  • Cyclosporine A, but not tacrolimus, reduced CXCR3 expression on Tregs.
  • Isolated Tregs exhibited functional regulatory activity, producing GARP mRNA.

Conclusions:

  • Peripheral trafficking receptors CXCR3 and CCR5 on Tregs are associated with renal allograft function.
  • Treg trafficking may be influenced by CXCR3/CCR5 interactions, with differential effects of immunosuppressants like tacrolimus and cyclosporine A.