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Human cytomegalovirus linked to stroke in a Chinese population

Zheng-Rong Huang1, Li-Ping Yu, Xin-Chun Yang

  • 1The First Affiliated Hospital, Xiamen University Medical School, Xiamen, China.

CNS Neuroscience & Therapeutics
|June 8, 2012
PubMed

Insights

Human cytomegalovirus (HCMV) infection is linked to a higher risk of stroke. This study found a significant association between HCMV and both ischemic and hemorrhagic stroke subtypes.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Cardiovascular Science

Background:

  • Human cytomegalovirus (HCMV) is associated with cardiovascular diseases.
  • The role of HCMV in stroke pathogenesis requires further investigation.

Purpose of the Study:

  • To evaluate the relationship between HCMV infection and stroke.
  • To determine if HCMV is a risk factor for stroke development.

Main Methods:

  • Plasma samples from 200 stroke patients and 200 controls were analyzed.
  • Real-time PCR and ELISA were used to detect HCMV infection.
  • Data were collected from the Stroke Hypertension Investigation in Genetics (SHINING) study.

Main Results:

  • HCMV seropositivity was significantly higher in stroke patients (55.0%) compared to controls (23.5%).
  • HCMV presence increased the risk of stroke by approximately fourfold (OR, 3.98).
  • This association remained significant for both ischemic and hemorrhagic stroke subtypes after adjusting for major risk factors.

Conclusions:

  • A novel link between HCMV infection and stroke is demonstrated.
  • HCMV may play a role in the pathogenesis of stroke.
  • Further research is warranted to explore HCMV's impact on stroke.
Abstract

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