Related Experiment Video
Updated: May 21, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
Published on: February 9, 2024
Developmental defects of the thyroid gland: relationship with advanced maternal age
Heves Kirmızibekmez1, Ayla Güven, Metin Yildiz
1Göztepe Education and Training Hospital, Department of Pediatric Endocrinology, İstanbul, Turkey. heveskirmizibekmez@yahoo.com
Objective:
Developmental defects of the thyroid gland are the most frequent causes of permanent congenital hypothyroidism. This study aimed to investigate the epidemiological features of patients with thyroid dysgenesis (TD).
Methods:
Medical records of 234 patients with TD followed between the years 2008 and 2010 were evaluated retrospectively. Diagnosis was made by ultrasonography.
Results:
Of 234 patients, 120 (51.3%) were male and 114 (48.7%) were female. Male to female ratio was 1.08 and there were no significant differences in epidemiologic and clinical findings between girls and boys. One hundred eighty-three patients (78.2%) were diagnosed as hypoplasia, 35 (14.9%) as thyroid agenesis, 4 as ectopic thyroid gland and 12 as hemiagenesis. The mean maternal age of the group was 28.9 ± 0.4 years (range 18 to 45 years), which is significantly higher than the recently reported mean maternal ages for Turkish women.
Conclusions:
Advanced maternal age was more prevalent in patients with TD. Our clinical and epidemiologic findings suggested no evidence of sexual dimorphism.
Related Concept Videos
Goiter
Hyperthyroidism II: Pathophysiology
Graves' Disease I: Introduction
Graves Disease II: Pathophysiology
Hypothyroidism II: Pathophysiology
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...