Related Experiment Video
Updated: May 21, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
3D hybrid wound devices for spatiotemporally controlled release kinetics
Ibrahim T Ozbolat1, Bahattin Koc
1Mechanical and Industrial Engineering Department, The University of Iowa, 2130 Seamans Center, Iowa City, IA 52242, USA. ibrahim-ozbolat@uiowa.edu
Abstract:
This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.
Related Concept Videos
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Rate-Programmed I
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

