Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Amnesia01:13

Amnesia

Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PET imaging utility of a novel Aβ-tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys.

Journal of translational medicine·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Age, glucose tolerance, and cognitive performance in female vervet monkeys.

GeroScience·2025
Same author

Neonatal sevoflurane exposure induces plasma biomarkers of inflammation in infant rhesus macaques.

Neurotoxicology and teratology·2025
Same author

The hippocampus dissociates present from past and future goals.

Nature communications·2024
Same author

A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry.

Oxford open neuroscience·2024

Related Experiment Video

Updated: May 21, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Quieting the overactive hippocampus restores memory in aging.

Mark G Baxter1

  • 1Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute, Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

Trends in Cognitive Sciences
|June 8, 2012
PubMed
Summary

A low dose of levetiracetam, an antiepileptic drug, reduced brain hyperactivity and improved memory in older adults with mild cognitive impairment. This suggests a potential new treatment for age-related memory decline.

More Related Videos

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice
08:58

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice

Published on: July 2, 2020

Related Experiment Videos

Last Updated: May 21, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice
08:58

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice

Published on: July 2, 2020

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Age-related memory impairment is a growing concern.
  • Amnestic mild cognitive impairment (MCI) is characterized by memory deficits.
  • Hippocampal hyperactivity is observed in individuals with MCI.

Purpose of the Study:

  • To investigate the effect of levetiracetam on hippocampal function in elderly individuals with amnestic MCI.
  • To determine if levetiracetam can improve memory function in this population.

Main Methods:

  • The study involved elderly humans diagnosed with amnestic mild cognitive impairment.
  • Participants received a low dose of the antiepileptic drug levetiracetam.
  • Hippocampal activity and memory function were assessed.

Main Results:

  • Levetiracetam significantly reduced hyperactivity in the hippocampus.
  • A low dose of levetiracetam improved hippocampal memory function.
  • These findings suggest a therapeutic potential for levetiracetam in MCI.

Conclusions:

  • Levetiracetam shows promise as a treatment for age-related memory impairment.
  • Reducing hippocampal overactivity may be a viable strategy for enhancing memory in MCI.
  • Further research is warranted to explore levetiracetam's long-term effects and optimal dosage.