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Nephrogenic adenoma in a urethral diverticulum.

Abhinav Sidana¹, Q J Zhai, Ayman Mahdy

¹Section of Voiding Dysfunction and Female Urology, Division of Urology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA. sidanaav@ucmail.uc.edu

|June 8, 2012

Summary

Nephrogenic adenoma (NA), a rare benign lesion, can occur anywhere in the urinary tract. This report details a unique case of NA developing within a urethral diverticulum.

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Area of Science:

Uropathology
Oncology
Surgical Pathology

Background:

Nephrogenic adenoma (NA) is a rare benign metaplastic lesion originating from the urothelium.
It typically arises in response to urothelial injury and chronic inflammation.
While most common in the bladder, NA can manifest in any urothelium-lined urinary tract region.

Observation:

This case report describes an unusual occurrence of nephrogenic adenoma.
The lesion was found to arise within a urethral diverticulum, a rare site for NA.
The clinical presentation and pathological features are detailed.

Findings:

Nephrogenic adenoma can histologically resemble urothelial carcinoma variants, clear cell adenocarcinoma, and prostate adenocarcinoma.
Accurate diagnosis necessitates a combination of histological examination and immunohistochemistry.
This case highlights the importance of considering NA in the differential diagnosis of urethral lesions.

Implications:

The diagnosis of NA requires careful evaluation to distinguish it from malignant neoplasms.
Immunohistochemistry plays a crucial role in differentiating NA from other conditions.
This case expands the known anatomical distribution of nephrogenic adenoma, emphasizing the need for vigilance in diagnosing lesions in unusual locations within the urinary tract.