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Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy
Zijuan Zhang1, Nicholas Kwiatkowski, Hong Zeng
1Department of Chemistry, University of Massachusetts Boston, Boston, MA 02125, USA. wei2.zhang@umb.edu
Molecular Biosystems
|June 8, 2012
Abstract:
As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.
