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Pharmacogenetics in perioperative medicine
Mindy Cohen1, Senthilkumar Sadhasivam, Alexander A Vinks
1Department of Anesthesiology, Children's Hospital Colorado, Aurora, USA. mindy.cohen@chidrenscolorado.org
Current Opinion in Anaesthesiology
|June 8, 2012
Summary
Pharmacogenetics influences how patients respond to common perioperative drugs, including analgesics and anesthetics. Future research may enable personalized perioperative medicine through genetic insights.
Area of Science:
- Pharmacogenetics
- Personalized Medicine
- Perioperative Care
Background:
- Pharmacogenetics studies genetic variations influencing drug response.
- Perioperative medications are crucial for patient management during surgery.
Purpose of the Study:
- Review recent advances in pharmacogenetics for perioperative medications.
- Discuss new collaborations in personalized medicine.
- Explore future clinical applications of pharmacogenetics.
Main Methods:
- Literature review of pharmacogenetic studies.
- Analysis of gene variants affecting drug metabolism and efficacy.
- Examination of research networks and consortia.
Main Results:
- Pharmacogenetics impacts analgesics (e.g., morphine), sedatives (e.g., midazolam), and local anesthetics (e.g., lidocaine).
- Genetic variants in CYP2C9, CYP3A4/5, and melanocortin-1 receptor influence drug response.
- CYP2D6, beta1, and beta2-receptor polymorphisms affect medications like metoprolol and preterm labor risk.
Conclusions:
- Pharmacogenetic approaches show promise for personalized perioperative interventions.
- Collaboration networks are advancing the field of personalized medicine.
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