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Updated: May 21, 2026

Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
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Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain

Published on: October 29, 2017

Subclinical zinc deficiency impairs human brain function.

Harold H Sandstead1

  • 1The University of Texas Medical Branch, Department of Preventive Medicine and Community Health, Division of Human Nutrition, Galveston, TX 77555-1109, USA. hsandste@mac.com

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|June 8, 2012
PubMed
Summary
This summary is machine-generated.

Subclinical zinc deficiency impairs brain function in diverse populations. Supplementation, especially with other micronutrients or a balanced diet, can improve brain health.

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Public Health

Background:

  • Zinc is vital for brain development and function across species.
  • Subclinical zinc deficiency is a potential risk factor for cognitive impairment.

Purpose of the Study:

  • To investigate the impact of subclinical zinc deficiency on brain function in various demographic groups.
  • To evaluate the efficacy of zinc supplementation, alone or combined with other interventions, in improving brain function.

Main Methods:

  • Conducted six randomized controlled comparative treatment experiments.
  • Included diverse populations: low-income Chinese and Mexican-American children (6-9 years), US adolescents, premenopausal women, and men.

Main Results:

  • Subclinical zinc deficiency was found to alter brain function across all studied groups.
  • Combined treatment with other micronutrients and/or an adequate omnivorous diet enhanced zinc's positive effects on brain function.

Conclusions:

  • Zinc plays a critical role in maintaining optimal brain function.
  • Addressing subclinical zinc deficiency through targeted supplementation and dietary improvements is crucial for cognitive health.