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Influenza A Virus Studies in a Mouse Model of Infection
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Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Clinical features of severe influenza A (H1N1) virus infection

Yinghu Chen1, Shiqiang Shang, Yongmin Tang

  • 1Division of Infection Disease, Zhejiang Key Laboratory for Neonatal Disease, Children's Hospital of Zhejiang University Medical College, Hangzhou, China.

Indian Journal of Pediatrics
|June 8, 2012
PubMed

Insights

Pediatric patients with severe influenza A (H1N1) infection often develop serious complications like ARDS, especially those under five years old. Early recognition of influenza-like illness with neurologic signs is crucial for timely diagnosis and treatment in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Critical Care Medicine

Background:

  • Influenza A (H1N1) poses a significant threat to pediatric populations.
  • Understanding clinical presentations aids in early diagnosis and management.

Purpose of the Study:

  • To delineate the clinical manifestations of influenza A (H1N1) in children.
  • To assist pediatricians in the early recognition and diagnosis of H1N1 infection.

Main Methods:

  • Retrospective review of medical records for pediatric inpatients diagnosed with influenza A (H1N1).
  • Study period: November 1, 2009, to May 31, 2011.

Main Results:

  • Eighty pediatric patients (median age 41.9 months) were analyzed.
  • Common complications included ARDS (11/80), pneumothorax (8/80), pleural effusion (7/80), and encephalopathy (7/80).
  • Mortality was concentrated in children under 5 with ARDS (6/11 deaths). Viral shedding averaged 11.4 days, longer than in adults.

Conclusions:

  • Young children constituted the majority of severe influenza A (H1N1) cases during the late pandemic wave.
  • Severe H1N1 infection in children increases susceptibility to complications, particularly ARDS, leading to mortality.
  • Influenza A (H1N1) should be suspected in pediatric cases of influenza-like illness with accompanying neurological symptoms.
Abstract

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