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Updated: May 21, 2026

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
[Bone infections]
A H Tiemann1, R Braunschweig, G O Hofmann
1Abteilung für Septische und Rekonstruktive Chirurgie, Klinik für Unfall -und Wiederherstellungschirurgie, BG-Kliniken Bergmannstrost Halle, Merseburgerstraße 165, 06112, Halle, Deutschland. andreas.tiemann@bergmannstrost.com
Abstract:
Even in recent traumatology and orthopedic surgery infectious diseases of the bone (i.e. osteomyelitis) and it's surrounding tissues remain serious complications. The therapy is demanding and oftenly does not lead to a complete restitutio ad integrum. In order to create the optimal treatment one has to have a profound knowledge about the "state of the art" therapy of bone infections and the basic phases: Reassurance of the local infection (bone and surrounding tissues) and reconstruction of the bone and surrounding tissues. The local infection treatment is based on the consequent surgical eradication of infected tissue. In addition (as a supportive therapy) antibiotics have to be applied according to the local and systemic response of the patient to the infection. Also further supportive methods like hyperbaric oxygenation may be taken into consideration. The following paper provides an overview of diagnostic features and the different surgical procedures as well as the current literature in order to reach the above mentioned goals.
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