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Related Experiment Video

Updated: May 21, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Structural and functional abnormalities in migraine patients without aura.

Chenwang Jin1, Kai Yuan, Limei Zhao

  • 1Department of Medical Imaging, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.

NMR in Biomedicine
|June 8, 2012
PubMed
Summary

Migraine patients show reduced gray matter volume in key brain areas and altered functional connectivity, particularly in the frontal cortex. These structural and functional changes correlate with disease duration, potentially explaining migraine-related impairments.

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Migraine is a common neurological disorder with recurrent attacks.
  • Previous research indicates structural and functional brain abnormalities in migraineurs.
  • Functional connectivity in the resting state of brain regions with structural deficits remains under-investigated.

Purpose of the Study:

  • To investigate structural deficits and resting-state functional connectivity alterations in migraine patients without aura.
  • To explore the relationship between these brain changes and disease duration.

Main Methods:

  • Voxel-based morphometry (VBM) for structural analysis.
  • Resting-state functional connectivity analysis using seed-based correlation.
  • Comparison between 21 migraine patients without aura and 21 healthy controls.

Main Results:

  • Migraine patients exhibited decreased gray matter volume in the left medial prefrontal cortex (MPFC), dorsal anterior cingulate cortex (dACC), right occipital lobe, cerebellum, and brainstem.
  • Increased functional connectivity was observed between the left dACC and bilateral middle temporal lobe, orbitofrontal cortex (OFC), and left dorsolateral prefrontal cortex (DLPFC).
  • Gray matter volume of the dACC and functional connectivity between the dACC, DLPFC, and OFC correlated with migraine duration.

Conclusions:

  • Migraine is associated with significant structural deficits and altered functional connectivity in specific brain regions.
  • These changes, particularly in the frontal cortex, may be influenced by chronic nociceptive input and contribute to functional impairments in migraine patients.