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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
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Small-sized carbon nanohorns enabling cellular uptake control.

Minfang Zhang1, Xin Zhou, Sumio Iijima

  • 1Nanotube Research Center, National Institute of Advanced, Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. m-zhang@aist.go.jp

Small (Weinheim an Der Bergstrasse, Germany)
|June 8, 2012
PubMed
Summary
This summary is machine-generated.

Small-sized single-walled carbon nanohorns (S-SWNHs) offer improved stealth and targeting capabilities for nanomedicine. These nanoparticles resist cellular uptake and can be functionalized for targeted delivery, overcoming limitations of larger carbon nanotubes.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Carbon nanotubes show promise in preclinical drug delivery and diagnostics.
  • Controlling nanoparticle size (<100 nm) is crucial to avoid nonspecific uptake and enable targeted delivery.
  • Current limitations hinder the widespread clinical application of carbon nanotubes.

Purpose of the Study:

  • To synthesize and characterize small-sized single-walled carbon nanohorns (S-SWNHs).
  • To evaluate the cellular uptake and stealth properties of S-SWNHs.
  • To demonstrate targeted cellular delivery of functionalized S-SWNHs.

Main Methods:

  • Oxidative exfoliation of pristine single-walled carbon nanohorn aggregates to obtain S-SWNHs (20-50 nm).
  • Assessment of S-SWNHs' resistance to cellular uptake by macrophages, tumor cells, and normal cells.
  • Functionalization of S-SWNHs with phospholipid polyethylene glycol (PEG) and folic acid (FA) for stealth and targeting.

Main Results:

  • S-SWNHs were synthesized with high yield (≥20%) and were highly hydrophilic.
  • S-SWNHs exhibited remarkable resistance to uptake by various cell types.
  • PEGylation of S-SWNHs significantly inhibited macrophage uptake; FA-functionalized S-SWNHs showed targeted uptake by folate receptor-overexpressing tumor cells.
  • Normal cells did not internalize FA-S-SWNHs, indicating specificity.

Conclusions:

  • S-SWNHs possess inherent stealth properties, resisting nonspecific cellular uptake.
  • Functionalization allows for controlled targeting of specific cell populations, such as tumor cells.
  • S-SWNHs demonstrate significant potential as advanced nanoparticles for medical applications due to their stealth and targeting capabilities.