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Related Experiment Video

Updated: May 21, 2026

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
09:22

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Published on: April 2, 2017

Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811.

Qinlong Liu1, Hasibur Rehman, Russell A Harley

  • 1Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, P.O. Box 250140, Charleston, SC 29425, USA.

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
|June 8, 2012
PubMed
Summary
This summary is machine-generated.

Small-for-size liver transplantation (LT) can cause lung injury. Pretreatment with NIM811 significantly reduced this pulmonary damage in rat models, highlighting its protective potential.

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Area of Science:

  • Transplantation immunology
  • Pulmonary medicine
  • Hepatology

Background:

  • Pulmonary complications are a major cause of mortality following liver transplantation (LT).
  • Small-for-size liver grafts are associated with increased complications.
  • The role of NIM811 in mitigating lung injury post-LT is unexplored.

Purpose of the Study:

  • To investigate if small-for-size LT exacerbates acute pulmonary injury.
  • To determine if NIM811 attenuates LT-associated lung injury in small-for-size grafts.

Main Methods:

  • Rat livers were reduced to 50% size and stored with or without NIM811.
  • Grafts were implanted into recipients, creating half-size (HSG) and quarter-size grafts (QSG).
  • Pulmonary and hepatic injury markers, including inflammation and apoptosis, were assessed.

Main Results:

  • QSG transplantation led to increased liver injury and suppressed regeneration.
  • Pulmonary histological alterations, including inflammation and apoptosis, were evident 38h post-LT in QSG recipients.
  • NIM811 pretreatment significantly reduced liver injury and attenuated pulmonary damage in QSG recipients.
  • NIM811 decreased hepatic TNFα, IL-1β, and pulmonary ICAM-1 expression.

Conclusions:

  • Dysfunctional small-for-size liver grafts release toxic cytokines, causing lung inflammation and injury.
  • NIM811 mitigates pulmonary injury after small-for-size LT by reducing toxic cytokine production.
  • NIM811 shows potential as a therapeutic agent to prevent lung injury post-liver transplantation.