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Oral lichen planus as a preneoplastic inflammatory model
Eleni A Georgakopoulou1, Marina D Achtari, Michael Achtaris
1Department of Histology and Embryology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.
Journal of Biomedicine & Biotechnology
|June 8, 2012
Summary
Oral lichen planus (OLP) is a potentially malignant disorder. Chronic inflammation in OLP may lead to DNA damage, potentially driving oral squamous cell carcinoma (OSCC) development.
Area of Science:
- Oral pathology
- Oncology
- Inflammation research
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting the oral mucosa.
- A subset of OLP patients (1-2%) may develop oral squamous cell carcinoma (OSCC).
- The World Health Organization classifies OLP as a potentially malignant disorder, but the underlying mechanisms are debated.
Purpose of the Study:
- To critically review the malignant potential of OLP.
- To explore the link between chronic inflammation in OLP and cancer development.
- To evaluate OLP as a model for preneoplastic inflammation.
Main Methods:
- Literature review focusing on molecular studies.
- Analysis of existing clinical data on OLP and OSCC.
- Critical assessment of current hypotheses on OLP's malignant transformation.
Main Results:
- Accumulated molecular data provides insights into OLP's malignant potential.
- Chronic inflammation is hypothesized to cause DNA damage, initiating cancer development.
- The progression from OLP to OSCC involves complex biological mechanisms.
Conclusions:
- OLP exhibits malignant potential, warranting further investigation.
- Understanding OLP's inflammatory pathways may offer insights into OSCC prevention.
- OLP serves as a relevant model for studying preneoplastic inflammation and its role in oral cancer.
