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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Ambulatory arterial stiffness index is higher in hypertensive patients with chronic kidney disease

Ronaldo Altenburg Gismondi1, Mario Fritsch Neves, Wille Oigman

  • 1Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.

International Journal of Hypertension
|June 8, 2012
PubMed

Insights

Hypertensive patients with chronic kidney disease (CKD) exhibit significantly higher arterial stiffness, measured by the Ambulatory Arterial Stiffness Index (AASI), compared to those without CKD. This indicates stiffer blood vessels in CKD patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Hypertension Research

Background:

  • Arterial stiffness is a cardiovascular risk factor.
  • Ambulatory Arterial Stiffness Index (AASI) is a validated measure from ambulatory blood pressure monitoring (ABPM).
  • Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity.

Purpose of the Study:

  • To compare AASI in non-diabetic hypertensive patients with and without CKD.
  • To investigate the relationship between AASI and CKD.
  • To assess arterial stiffness in hypertensive patients with varying renal function.

Main Methods:

  • Comparison of AASI between hypertensive patients with normal renal function and those with CKD (eGFR <60 mL/min).
  • Utilized ambulatory blood pressure monitoring (ABPM) for AASI calculation.
  • Statistical analysis to determine significant differences and correlations.

Main Results:

  • Mean 24-hour systolic and diastolic blood pressure were similar between groups.
  • AASI was significantly higher in the CKD group (0.45 ± 0.03) versus the non-CKD group (0.37 ± 0.02).
  • AASI positively correlated with age and pulse pressure, and negatively with nocturnal blood pressure fall.

Conclusions:

  • Hypertensive patients with CKD demonstrate increased arterial stiffness.
  • Elevated AASI in CKD patients suggests stiffer vessels.
  • AASI may serve as a marker for cardiovascular risk in hypertensive patients with CKD.

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