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Updated: May 21, 2026
Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
"Embryo glue" does not seem to improve chances of subsequent pregnancy in refractory in vitro fertilization cases
J H Check1, D Summers-Chase, W Yuan
1The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
Purpose:
To determine if the use of Embryo glue improves implantation and pregnancy rates following embryo transfer (ET) in women who failed to conceive in three previous attempts.
Methods:
A matched controlled study was performed in women undergoing IVF-ET, donor oocyte recipients and women using their own oocytes having fresh or frozen ETs. A woman having Embryo glue was matched with the very next woman not using glue within six months of age and having the same number of previous failed ETs.
Results:
Embryo glue did not seem to improve pregnancy or implantation rates. In fact, in evaluating fresh embryo transfers there was a significantly higher live delivered pregnancy rate in the women not using Embryo glue (39.3%) vs those using the glue (14.3%).
Conclusions:
Embryo glue does not improve pregnancy outcome in women failing in previous IVF cycles.
