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Related Experiment Videos

Adrenocortical function in patients with pulmonary tuberculosis.

G R Sarma1, C Immanuel, G Ramachandran

  • 1Tuberculosis Research Centre (Indian Council of Medical Research), Madras.

Tubercle
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Pulmonary tuberculosis disrupts adrenocortical function, leading to elevated plasma cortisol levels and impaired responses to ACTH stimulation in patients. Cortisol secretion patterns also show significant diurnal variations in tuberculosis compared to healthy individuals.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Infectious Diseases

Background:

  • Adrenocortical function is crucial for maintaining homeostasis.
  • Pulmonary tuberculosis is a significant global health challenge.
  • Altered endocrine function may occur in chronic infections.

Purpose of the Study:

  • To investigate adrenocortical function in patients with pulmonary tuberculosis.
  • To compare cortisol levels and responses to stimulation between tuberculosis patients and healthy subjects.
  • To analyze diurnal variations in cortisol secretion in tuberculosis.

Main Methods:

  • Measurement of plasma cortisol levels in newly diagnosed and chronic tuberculosis patients, and healthy controls.
  • Assessment of adrenocortical response using ACTH (tetracosactrin) stimulation.

Related Experiment Videos

  • Evaluation of diurnal cortisol secretion patterns (08:00 to 20:00).
  • Effect of dexamethasone on plasma cortisol levels was also observed.

    • Main Results:

    • Newly diagnosed tuberculosis patients exhibited significantly higher plasma cortisol levels than healthy subjects (P < 0.001).
    • A significantly lower percentage of tuberculosis patients (newly diagnosed: 56%; chronic: 42%) showed a normal response to ACTH stimulation compared to healthy subjects (97%) (P < 0.001).
    • Tuberculosis patients displayed an altered diurnal cortisol rhythm, with a significant increase after 16:00, unlike the steady decline in healthy individuals.

    Conclusions:

    • Pulmonary tuberculosis is associated with significant disturbances in adrenocortical function.
    • Impaired cortisol response to ACTH stimulation is evident in tuberculosis patients.
    • Diurnal cortisol secretion patterns are disrupted in individuals with pulmonary tuberculosis, suggesting a complex interplay between infection and the hypothalamic-pituitary-adrenal axis.