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Updated: May 21, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Restoration of a peri-implant defect by platelet-rich fibrin
Jong-Won Lee1, Seong-Gon Kim, Jwa-Young Kim
1Resident, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Republic of Korea.
Objective:
The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo.
Study Design:
Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.0 × 5.0 mm (width × length) were prepared after drilling to host the dental implant in the tibia. Subsequently, the 2 dental implants were installed (diameter, 3.0 mm and length, 8.0 mm). In the experimental group, PRF was applied into the bony defect. In the control group, the peri-implant defect was left unfilled. The animals were humanely killed 8 weeks after implantation and histomorphometric analysis was done.
Results:
In the histomorphometric analysis, mean new bone formation was 29.30% ± 7.50% in the experimental group and 11.06% ± 8.94% in the control group (P = .020). Mean bone-to-implant contact was 39.43% ± 7.39% in the experimental group and 17.11% ± 8.12% in the control group (P = .006).
Conclusions:
In the animal model, peri-implant defect sized 3.0 × 5.0 mm (width × length) was successfully repaired by the application of PRF alone.
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