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Psychometric performance of the CushingQoL questionnaire in conditions of real clinical practice

Alicia Santos1, Eugenia Resmini, Ma Antonia Martínez-Momblán

  • 1Endocrinology/Medicine Department, Hospital de Sant Pau, IIB-Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER Unit 747), ISCIII, Universitat Autònoma de Barcelona (UAB), C/Sant Antoni Maria Claret 167, 08025 Barcelona, Spain.

European Journal of Endocrinology
|June 9, 2012
PubMed

Insights

The CushingQoL questionnaire accurately measures health-related quality of life in Cushing's syndrome (CS). It demonstrates reliable test-retest results and sensitivity to treatment changes in patients.

Area of Science:

  • Endocrinology
  • Clinical Psychology

Background:

  • Cushing's syndrome (CS) significantly impacts patients' health-related quality of life (HRQoL).
  • Assessing HRQoL is crucial for managing CS and evaluating treatment efficacy.
  • The disease-specific CushingQoL questionnaire was developed to address this need.

Purpose of the Study:

  • To evaluate HRQoL in CS patients using the CushingQoL questionnaire.
  • To confirm the psychometric properties of the CushingQoL, specifically its test-retest reliability and sensitivity to change.

Main Methods:

  • A cohort of 59 CS patients was studied in a tertiary referral center.
  • The CushingQoL and EuroQoL questionnaires were administered at baseline and during follow-up.
  • Test-retest reliability was assessed in stable patients, while sensitivity to change was evaluated in patients post-successful surgery.

Main Results:

  • CushingQoL scores were significantly lower in active CS patients compared to cured patients (P<0.05).
  • The questionnaire demonstrated good test-retest reliability in both stable cured (ICC=0.78) and active (ICC=0.66) patient groups.
  • CushingQoL showed significant sensitivity to clinical improvement following surgery, with increasing scores at 4 and 9 months post-operation.

Conclusions:

  • The CushingQoL questionnaire is a reliable and valid instrument for assessing HRQoL in CS patients.
  • It exhibits strong test-retest reliability and sensitivity to treatment-induced changes in clinical practice.
  • CushingQoL is a valuable tool for monitoring patient outcomes in CS management.
Abstract

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