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Documentation of functional and clinical effects of infant nutrition: setting the scene for COMMENT

Berthold Koletzko1, Hania Szajewska, Margaret Ashwell

  • 1Dr. von Hauner Children's Hospital, University of Munich Medical Centre, Germany. office.koletzko@med.uni-muenchen.de

Annals of Nutrition & Metabolism
|June 9, 2012
PubMed

Insights

Establishing evidence-based guidelines for pediatric nutrition trials is crucial. The Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical Trials (COMMENT) aims to define outcome measures and core data sets for infants and young children.

Area of Science:

  • Pediatric Nutrition
  • Clinical Trial Methodology
  • Evidence-Based Medicine

Background:

  • A 2011 workshop convened by the Early Nutrition Academy and Child Health Foundation addressed evidence acquisition for nutritional interventions in young children.
  • Collaboration involved the European Society for Paediatric Gastroenterology, Hepatology and Nutrition's Committee on Nutrition.

Purpose of the Study:

  • To provide guidance on evidence quality and quantity for nutritional effects in children under 3 years.
  • To establish agreed outcome measures and criteria for pediatric nutrition trials.
  • To update the core data set for infant and young child nutrition studies.
  • To offer guidance on using surrogate markers in pediatric nutrition research.

Main Methods:

  • Formation of the Consensus Group on Outcome Measures Made in Paediatric Enteral Nutrition Clinical Trials (COMMENT).
  • Establishment of six working groups to define criteria for key outcomes (growth, diarrhea, allergy, infections, gut comfort) and update the core data set.
  • Development of a consensus methodology for all working groups.

Main Results:

  • Agreement to establish working groups under the COMMENT initiative.
  • Focus on defining criteria for growth, acute diarrhea, atopic dermatitis, cow's milk protein allergy, infections, and gut comfort.
  • Commitment to review and update the core data set for nutrition trials.

Conclusions:

  • The COMMENT group will define standardized outcome measures and data collection for pediatric nutrition research.
  • Future meetings are planned within two years to report and publish consensus findings.
  • This initiative aims to improve the quality and comparability of evidence from pediatric nutrition trials.

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