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Updated: May 21, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
First diastereoselective synthesis of methyl caffeoyl- and feruloyl-muco-quinates
Rakesh Jaiswal1, Michael H Dickman, Nikolai Kuhnert
1Jacobs University Bremen, Bremen, Germany.
Abstract:
We report on a diastereoselective synthesis of six derivatives of caffeoyl- and feruloyl-muco-quinic acids. All the muco-quinic acid derivatives were obtained in excellent yield in five steps starting from quinic acid, caffeic acid and ferulic acid. Allyl ether protection of trans-hydroxy cinnamic acids was here introduced to chlorogenic acids synthesis. We show that muco-quinic acid derivatives, which are formally diastereoisomers of chlorogenic acids, can be readily distinguished by their tandem mass spectra.
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