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Updated: May 21, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children
Giorgio Ciprandi1, Caterina Cuppari, Anna Maria Salpietro
1Azienda Ospedaliera Universitaria San Martino, IRCCS, Genoa, Italy. gio.cip@libero.it
Background:
Recently, Th17 cells have been found to participate in the pathogenesis of allergic asthma. IL-23 is a cytokine that may be implicated in modulating Th17 response. This study aimed at evaluating IL-23 and relating it to lung function in asthmatic children.
Methods:
Seventy-eight asthmatic children and 40 healthy children were evaluated. Spirometry and serum IL-23 measurement (ELISA kit) were performed in all asthmatic children.
Results:
IL-23 levels were higher in asthmatic than in healthy children (p < 0.001). There was a strong inverse relationship between FEV(1) and IL-23 (r = -0.787).
Conclusions:
This preliminary study suggests that serum IL-23 could be a suitable marker of bronchial function impairment in allergic asthmatic children.
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