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08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Inflammatory bowel disease surgery in the biologic therapy era
1Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA. strongs@ccf.org
Current Opinion in Gastroenterology
|June 9, 2012
Summary
Biologic agents offer limited improvement in inflammatory bowel disease management, with surgery still frequently needed. Future research should explore combining surgery and biologics for better disease control and value.
Area of Science:
- Gastroenterology
- Surgical Management
- Pharmacology
Background:
- Inflammatory bowel disease (IBD) management involves surgery and biologic agents.
- The interplay between these treatment modalities is of significant clinical interest.
Purpose of the Study:
- To review the current relationship between surgical interventions and biologic therapies in IBD patient care.
- To assess the evolving role and limitations of biologic agents in Crohn's disease and ulcerative colitis.
Main Methods:
- Literature review of studies on surgery and biologics in IBD.
- Analysis of clinical outcomes, cost-effectiveness, and quality of life data.
Main Results:
- Biologic therapies have marginally reduced the need for surgery in IBD.
- Biologics may increase infectious complications in non-elective surgical settings.
- Biologics are costly and may not significantly improve quality of life compared to surgery.
Conclusions:
- Current biologic agents are not a complete solution for IBD.
- Future research should focus on integrated approaches combining surgery and novel biologics.
- The goal is to achieve safe inflammatory disease control with demonstrable value.
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