[The correction of the endothelial dysfunction by the experimental biliary peritonitis]

The purpose of the study is to increase the effectiveness of treatment of biliary peritonitis. The studies strongly suggest that in the early stages of the animals biliary peritonitis development against the background of endogenous intoxication in the body occur metabolic and functional disorders. The reason of this disorders is endothelial dysfunction with the violation of synthesis of such biologically active substances as endothelin-1, NO, von Willebrand factor and cytokines in the blood plasma. All of this leads to a change of the number of desquamated endotheliocytes and lymphocyte-platelet adhesion. The detected violation of the studied endothelial dysfunction markers production in choleperitonitis can be regarded as a new direction in improving the diagnosis of biliary peritonitis. The omni directional end-effects of the used methods of treatment to the endothelium functional state, which were identified in comparative analysis in the most cases, suggest that pathogenetic flow paths of biliary peritonitis in the studied groups are different and require further detailed study.