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Renal hypertension in rats with hereditary polycystic kidney disease
J Kaspareit-Rittinghausen1, F Deerberg, K G Rapp
1Central Institute for Laboratory Animal Breeding, Hannover, F.R.G.
Zeitschrift Fur Versuchstierkunde
|January 1, 1990
Abstract:
Hereditary polycystic kidney disease (PKD) was observed in a Han:SPRD rat mutant. Cysts were of tubular origin and occurrence was more pronounced in males than in females. In male rats polycystic kidney disease was associated with a marked elevation of systolic blood pressure. Therefore this rat mutant can be considered as a laboratory animal model for renal hypertension associated with adult polycystic kidney disease in man.