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Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
Published on: February 22, 2016
Design of vesicles using capillary microfluidic devices: from magnetic to multifunctional vesicles
Anjali Seth1, Gaëlle Béalle, Enric Santanach-Carreras
1Laboratoire de Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques (PECSA), UMR 7195, Équipe Colloïdes Inorganiques, Université Paris 6 (UPMC) Bat F(74), case 51, 4 place Jussieu, F-75252 Paris Cedex 05, France.
Advanced Materials (Deerfield Beach, Fla.)
|June 9, 2012
Summary
This study introduces a microfluidic device for creating magnetic liposomes and polymersomes by modifying nanoparticle surfaces. The method efficiently produces hybrid vesicles with uniform size distribution.
Area of Science:
- Materials Science
- Nanotechnology
- Biotechnology
Background:
- Vesicles like liposomes and polymersomes are crucial in drug delivery and diagnostics.
- Controlling nanoparticle integration within vesicle structures remains a challenge.
Purpose of the Study:
- To develop a microfluidic method for precisely designing magnetic vesicles.
- To explore the incorporation of various nanoparticles (hydrophilic, hydrophobic, quantum dots) into vesicle cores or shells.
Main Methods:
- Utilized a microfluidic device for vesicle fabrication.
- Employed chemical modification of nanoparticle surfaces for integration.
- Incorporated hydrophilic, hydrophobic, and quantum dot nanoparticles.
Main Results:
- Successfully designed magnetic liposomes and polymersomes with nanoparticles in the core, shell, or both.
- Achieved high yields and excellent monodispersity for hybrid vesicles.
- Demonstrated versatility in nanoparticle incorporation.
Conclusions:
- The microfluidic approach offers precise control over magnetic vesicle design.
- This method facilitates the efficient production of monodisperse hybrid vesicles for advanced applications.
