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Updated: May 21, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
'Goose bumps'-associated anaemia
Chisho Hoshino1, Akane Yamabe, Yoshiyuki Sekikawa
1Department of General Internal Medicine, Ohta-Nishinouchi Hospital, Koriyama City, Fukushima, Japan. gim-hoshino@ohta-hp.or.jp
Abstract:
A 36-year-old woman presented to our hospital for further evaluation of anaemia screened by regular check-up. She was diagnosed with iron-deficiency anaemia (IDA) but refractory to iron supplementation. She had negative results of occult blood in the stool and no gynaecologic disease potentially causing hyper menorrhea. Upper endoscopy revealed a nodular gastritis, which has been called 'Torihada-ien', a Japanese word meaning 'gastritis with goose bumps-like appearance', associated with Helicobacter pylori (Hp) infection. After Hp eradication therapy, her anaemia resolved with an improved response to iron supplementation. In an unexplained IDA patient, Hp-associated gastritis should be considered in the possible background.
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