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Updated: May 21, 2026
09:37
Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy
Published on: August 15, 2014
New molecular insights into CETP structure and function: a review.
M Arthur Charles1, John P Kane
1Department of Medicine University of California, San Francisco, CA 94158, USA. art.charles@ucsf.edu
Journal of Lipid Research
|June 9, 2012
Summary
Cholesteryl ester transfer protein (CETP) is a drug development target. New research clarifies its molecular mechanism and interactions with lipoproteins, improving understanding of lipid transfer.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Cholesteryl ester transfer protein (CETP) plays a crucial role in lipid metabolism.
- CETP is a significant target for novel drug development.
- The precise structure and mechanism of CETP action remain incompletely understood.
Purpose of the Study:
- To elucidate the molecular mechanism of CETP function.
- To understand CETP's interactions with lipoproteins at a molecular level.
- To provide insights for the development of CETP-targeted therapeutics.
Main Methods:
- Integration of novel structural and functional methodologies.
- Comparative analysis with existing experimental data.
- Molecular-level functional step analysis.
Main Results:
- Proposed a multi-step model for CETP function: sensing, penetration, docking, selectivity, ternary complex formation, lipid transfer, and HDL dissociation.
- Detailed the molecular interactions between CETP and lipoproteins.
- Provided new structural and functional insights into CETP activity.
Conclusions:
- The study enhances the understanding of CETP's mechanism of action.
- These findings offer a foundation for rational drug design targeting CETP.
- Improved comprehension of CETP's role in lipid transfer and metabolism.
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