Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond R2: Assessing quality of trial level surrogate endpoints in colorectal cancer.

Journal of the National Cancer Institute·2026
Same author

Gastrointestinal malignancies in pregnancy: practical considerations.

Journal of gastrointestinal oncology·2026
Same author

Trends in primary surgery and overall survival in non-metastatic anal cancer: a population-based analysis.

The oncologist·2026
Same author

Integrating oncology advanced practice providers and clinical pharmacists into clinical cancer research.

Journal of the National Cancer Institute·2026
Same author

Trends in primary surgery and overall survival in non-metastatic anal cancer: a population-based analysis.

The oncologist·2026
Same author

ACR Appropriateness Criteria® Staging and Follow-Up of Pancreatic Neuroendocrine Tumors.

Journal of the American College of Radiology : JACR·2026
Same journal

Measuring Equitable Care Delivery: Insights From the Health Equity Report Card (HERC) Pilot in Academic Cancer Centers.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

A Virtual Reality Psychosocial Intervention for Patients Undergoing Bone Marrow Transplantation (BMT-VR): Pilot Randomized Clinical Trial.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Nationwide Trends in Colorectal Cancer Screening by the End of the COVID-19 Pandemic: Racial/Ethnic Differences and Opportunities.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Evaluation of the Impact of Adjuvant Immunotherapy in Merkel Cell Carcinoma.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Payers' Views on Insurance Coverage for Confirmatory Diagnostics After a Noncovered Multicancer Early Detection (MCED) Test.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Surrogacy of Intermediate Clinical Endpoints for Overall Survival in Patients With Localized Muscle-Invasive Bladder Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
See all related articles

Related Experiment Videos

Neuroendocrine tumors.

Matthew H Kulke1, Al B Benson, Emily Bergsland

  • 1Dana-Farber/Brigham and Women’s Cancer Center.

Journal of the National Comprehensive Cancer Network : JNCCN
|June 9, 2012
PubMed
Summary
This summary is machine-generated.

This updated guideline provides comprehensive information on diagnosing and managing neuroendocrine tumors, including carcinoid and pancreatic neuroendocrine tumors. It features new pathology sections and revised surgical recommendations for pancreatic neuroendocrine tumors.

Related Experiment Videos

Area of Science:

  • Oncology
  • Endocrinology
  • Surgical Pathology

Background:

  • Neuroendocrine tumors (NETs) represent a diverse group of neoplasms, with carcinoid tumors and pancreatic NETs being the most prevalent.
  • Existing NCCN Guidelines offer a framework for managing sporadic and hereditary NETs, primarily focusing on well-differentiated, low- to intermediate-grade malignancies.

Purpose of the Study:

  • To present an updated version of the NCCN Neuroendocrine Tumors Guidelines.
  • To incorporate new diagnostic and reporting standards for NET pathology.
  • To revise surgical management recommendations specifically for pancreatic NETs.

Main Methods:

  • Review and synthesis of current evidence and expert consensus on NET diagnosis and management.
  • Inclusion of a new dedicated section on pathology for NET diagnosis and reporting.
  • Revision of surgical treatment algorithms for pancreatic neuroendocrine tumors.

Main Results:

  • The updated guidelines now feature a comprehensive pathology section crucial for accurate NET diagnosis and classification.
  • Revised recommendations provide updated surgical approaches for managing pancreatic neuroendocrine tumors.
  • The guidelines continue to address both sporadic and hereditary forms of NETs, emphasizing well-differentiated tumors.

Conclusions:

  • This updated NCCN Guideline version enhances the diagnostic and reporting capabilities for neuroendocrine tumors through an improved pathology section.
  • The revised surgical management strategies for pancreatic neuroendocrine tumors aim to optimize patient outcomes.
  • These guidelines serve as a vital resource for the multidisciplinary care of patients with neuroendocrine tumors.